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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: combating viral infection, the intercellular transfer of pathogen and host-derived materials and their epigenetic

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: It culminates in desirable changes in the structural and textural properties and is governed by a complexAdditional regulatory factors such as transcription factors (TFs) and epigenetic modifications also playevaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: It culminates in desirable changes in the structural and textural properties and is governed by a complexAdditional regulatory factors such as transcription factors (TFs) and epigenetic modifications also playevaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic and epigeneticIn addition to genetic alteration, epigenetic modifications, and in particular DNA methylation, are recognizedThis review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection

Keywords： epigenetics     DNA methylation     esophageal cancer     dysplasia    

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environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 176-184 doi: 10.1007/s11684-021-0885-y

Abstract: Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the offspring. However, studies that explore the mechanisms that meditate this transmission are rare. Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure, and the methodology of microinjection of isolated total RNA or sncRNAs or synthetically identified sncRNAs gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male line. Hence, by reviewing relevant literature, this study intends to answer the following research concepts: (1) paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncRNAs, (2) potential role of paternal spermatozoal sncRNAs during the intergenerational inheritance process, and (3) the potential mechanism by which spermatozoal sncRNAs meditate intergenerational inheritance. In summary, increased attention highlights the hidden wonder of spermatozoal sncRNAs during intergenerational inheritance. Therefore, in the future, more studies should focus on the origin of RNA alteration, the target of RNA regulation, and how sncRNA regulation during embryonic development can be sustained even in adult offspring.

Keywords： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

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Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 370-373 doi: 10.1007/s11684-008-0071-5

Abstract: It is well known that high concentration oxygen exposure is a model of acute lung injury (ALI). However, controversy exists over the mechanism. This study was designed to clarify the cellular characteristics in bronchoalveolar lavage fluid (BALF) and body weight loss of rats exposed to oxygen(> 90%). Young male Wistar rats, aged 6 weeks, were divided into three groups: (1) room air group (exposed to room air, = 22); (2) hyperoxia < 48 h group (exposed to over 90% oxygen for less than 48 h, = 18); (3) hyperoxia 66–72 h group (exposed to over 90% oxygen for 66–72 h group, = 7). Compared to the room air group, the total cell counts in the hyperoxia 66–72 h group decreased, whereas the neutrophils increased significantly. The body weights of the rats exposed to room air continued to increase. However, the body weights of oxygen-exposed rats increased slightly on the first day and weight loss was seen from the second day. All rats were noted to have bilateral pleural effusion in the hyperoxia 66–72 h group. The data suggests that (1) an increase in neutrophil count is an evident feature of hyperoxia-induced lung injury; (2) high concentration oxygen exposure can give rise to anorexia and malnutrition, which may play a role in hyperoxia-induced lung injury. Blocking neutrophil influx into lung tissue in the early phase and improving malnutrition are two effective methods to reduce hyperoxic lung injury.
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Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1738-5

Abstract: List>

● A novel integrated machine learning method to analyze O3 changes

Keywords： Ozone     Integrated method     Machine learning    

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From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 191-200 doi: 10.1007/s11684-013-0258-2

Abstract: potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changesHowever, the exact changes and their relative importance in the metabolic improvements after gastric

Keywords： gastric bypass     T2DM     gut    

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Study on microbial protein and the mechanism of solid-state fermentation with periodical dynamic changes

FU Xiaoguo, CHEN Hongzhang, LI Hongqiang, MA Runyu

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 2,   Pages 113-117 doi: 10.1007/s11705-007-0021-9

Abstract: microbial protein obtained from solid-state fermentation (SSF) and the effect of periodical dynamic changesThe mechanism of solid-state fermentation with periodical dynamic changes of air is also discussed.Compared with static solid-state fermentation, periodical dynamic changes of air afford a higher proteinactivity of the microbial extracellular protein in solid-state fermentation with periodical dynamic changesof air on the fifth day is nearly equal to that on the sixth day without periodical dynamic changes
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The temporal changes of the concentration level of typical toxic organics in the river sediments around

Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 6, doi: 10.1007/s11783-018-1054-7

Abstract:

The current situation of typical organics in the sediments around Beijing was unclear.

56 kinds of typical toxic organics were detected in this article.

Historical data was compared with the data in this study.

The change of different organics in the sediments around Beijing was concluded.

Keywords： Organic compounds     Endocrine disrupters     Sediments     Concentration     Temporal changes    

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Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 231-241 doi: 10.1007/s11684-013-0253-7

Abstract:

Hepatocellular carcinoma (HCC) development is characterized by the presence of epigenetic alterationsIn this review, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylationour understanding on the roles of PcG proteins in hepatocarcinogenesis can benefit the development of epigenetic-based

Keywords： liver cancer     epigenetics     histone modifications     polycomb group proteins     enhancer of zeste homolog 2 (EZH2)    

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Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1458-7

Abstract:

•Tryptophan protein, and aromatic protein I/II were the key identified proteins.

Keywords： Sludge pretreatments     Dissolved organic nitrogen     Proteins     Amino acids     Structural equation model     Metagenomic sequencing analysis.    

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Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the

GUO Tiecheng, CAO Xuebing, XIA Limin

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 406-409 doi: 10.1007/s11684-008-0078-y

Abstract: This article is to explore if rTMS can cause changes of such chemical substances as N-acetylaspartateIt is concluded that rTMS could result in changes of the chemical substance contents in perihematomal
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Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 429-441 doi: 10.1007/s11684-021-0842-9

Abstract: local microenvironment is essential to stem cell-based therapy for ischemic stroke, and spatiotemporal changesHowever, relevant studies on microenvironmental changes were mainly confined in the acute phase of stroke, and long-term changes remain unclear.This study aimed to investigate the microenvironmental changes in the subacute and chronic phases ofa positive therapeutic effect in ischemic stroke and emphasized the wide-ranging microenvironmental changes

Keywords： ischemic stroke     microenvironment     induced pluripotent stem cells (iPSCs)     positron emission tomography (PET)     quantitative proteomics    

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Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1569-9

Abstract:

● Fe3O4 NPs increased the biomass and chlorophyll content of hemp clones.

Keywords： Fe3O4 nanoparticle     Hemp     Growth enhancement     THC     Metabolite    

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Title Author Date Type Operation

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Journal Article

environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic

Journal Article

Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

Journal Article

Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method

Journal Article

From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Journal Article

Study on microbial protein and the mechanism of solid-state fermentation with periodical dynamic changes

FU Xiaoguo, CHEN Hongzhang, LI Hongqiang, MA Runyu

Journal Article

The temporal changes of the concentration level of typical toxic organics in the river sediments around

Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong

Journal Article

Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Journal Article

Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Journal Article

Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the

GUO Tiecheng, CAO Xuebing, XIA Limin

Journal Article

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Journal Article

Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)

Journal Article